Total cholesterol (AUC = 0.626, p = 0.013), LDL cholesterol (AUC = 0.670, p = 0.001), and TC/HDL (AUC = 0.620, p = 0.019) significantly classified subjects as insulin-resistant, with LDL cholesterol showing the highest AUC for the classification of insulin resistance. The gene discussed is INS; the disease is Insulin resistance.