MAPT and early-onset autosomal dominant Alzheimer disease: Several research papers demonstrated that Alzheimer's disease during pregnancy causes cognitive impairment in the neonates, and possible treatment starting early from prenatal to early postnatal periods may prevent cognitive deficits, reduce Tau and amyloid pathologies, and decrease postsynaptic deficits and neuroinflammation in the brain at the adult stage in 3xTg-AD mice [44].