As shown in Figure 2a–f, the concentrations of 25(OH)-VD3 (Figure 2a and b) and VDR (Figure 2c and d) were remarkably attenuated in rat and human serum of liver cirrhosis, and in contrast, augmented levels of CYP24A1 (Figure 2e and f) were detected compared with the control group. The gene discussed is VDR; the disease is cirrhosis of liver.