The output of AMD reveals that a large portion of outgoing fibroblast signaling is characterized by Pattern #1, which represents multiple pathways, including but not limited to AGT, BAFF, CSF3, CXCL, GH, IL1, LT, MK, MSTN, PDGF, and WNT (Supplementary Figure S7A). This evidence concerns the gene CSF3 and age-related macular degeneration.