Integrated DEGs, gene expression patterns, and transcriptional regulons results, we found that the perturbation of 7 transcription factors, including NFYB, MAF, TCF7, FOXO1, IRF9, STAT1, and STAT2 between AMD patients and controls, might play momentous parts in the development of AMD. Here, TCF7 is linked to age-related macular degeneration.