Integrated DEGs, gene expression patterns, and transcriptional regulons results, we found that the perturbation of 7 transcription factors, including NFYB, MAF, TCF7, FOXO1, IRF9, STAT1, and STAT2 between AMD patients and controls, might play momentous parts in the development of AMD. The gene discussed is STAT1; the disease is age-related macular degeneration.