In contrast, the incoming communication patterns of AMD (Supplementary Figure S7B) show that endothelial cells, fibroblasts, and RPE cells were dominated by Pattern #1, which includes signaling pathways such as AGT, BAFF, CSF3, GH, GP1BA, LT, MSNT, NRXN, PARs, SPP1, and WNT, as well as CD46, CDH5, EGF, IFN–II, JAM, LIGHT, PDGF, TGFb, and VCAM among others. Here, SPP1 is linked to age-related macular degeneration.