In contrast, the incoming communication patterns of AMD (Supplementary Figure S7B) show that endothelial cells, fibroblasts, and RPE cells were dominated by Pattern #1, which includes signaling pathways such as AGT, BAFF, CSF3, GH, GP1BA, LT, MSNT, NRXN, PARs, SPP1, and WNT, as well as CD46, CDH5, EGF, IFN–II, JAM, LIGHT, PDGF, TGFb, and VCAM among others. This evidence concerns the gene CSF3 and age-related macular degeneration.