We spotted that CD70-CD27 (CD70 pathway), CX3CL1-CX3CR1 (CX3C pathway), SELE-CD44 (SELE pathway), and TNF-TNFRSF1A (TNF pathway), which have been reported to play critical roles in inflammatory and immune response, were erased in AMD patients, implying their impact on the inflammation and immune response in AMD. This evidence concerns the gene CD44 and age-related macular degeneration.