NFYB regulon was more activating in endothelial cells (fold change = 7.44), fibroblasts (fold change =3.27), macrophages (fold change =2.31), and mast cells (fold change =3.49), while relatively silent in T/NK cells (fold change < −10) in AMD than controls. Here, NFYB is linked to age-related macular degeneration.