The output of AMD reveals that a large portion of outgoing fibroblast signaling is characterized by Pattern #1, which represents multiple pathways, including but not limited to AGT, BAFF, CSF3, CXCL, GH, IL1, LT, MK, MSTN, PDGF, and WNT (Supplementary Figure S7A). Here, LTA is linked to age-related macular degeneration.