The onset of symptoms in our colony of hSOD1-G93A was delayed relative to the source founders (Broadhead et al., 2022) However, all mice allowed to survive developed symptoms, and consistent with disease onset, body weight (Table 1) was reduced at this early symptomatic stage of ALS progression (p < 0.001, Student’s t-test). Here, SOD1 is linked to amyotrophic lateral sclerosis.