SOD1 and Tremor: To investigate whether spontaneous mEPP transmission deficits appeared in hSOD1-G93A NMJs, mEPP amplitudes were compared across the full age-range in wildtype and hSOD1-G93A mice, i.e., at 2, 4, 8, 12, 16  weeks, plus early symptomatic stages (hindlimb tremor first evident) of 18–22 weeks old, which were age-matched with wildtype littermates.