The addition of echocardiographic assessment (elevated LAP) and probability of elevated PAWP significantly improved the ability of a model containing the Yale-CORE HF score, eGFR, and log BNP (model 1), Yale-CORE HF score, χ2 = 4.4 (model 2), plus eGFR and log BNP, χ2 = 16.8, p = 0.001 (model 3), plus elevated LAP, χ2 = 24.4, p = 0.005, plus probability of elevated PAWP on pre-discharge, χ2 = 41.1, p < 0.001). The gene discussed is NPPB; the disease is hydrops fetalis.