The missense variants in the MYH7 gene, which considered LPVs per the American College of Medical Genetics (ACMG) guidelines, were the second most frequent variants in the study populations and were detected more commonly in DCM (18/1,041, 1.7%) and IDCM (5/215, 2.3%), as compared to the control population (3/414,0.7%), as shown in Table 3. This evidence concerns the gene MYH7 and familial dilated cardiomyopathy.