In order to develop a more effective photodynamic therapy (PDT) method for ovarian cancer, we evaluated the anti-tumor activity of our developed biomimetic nano@microgel systems, including Au@MSN-Ter/THPP@CM NPs and Au@MSN-Ter/THPP@CM@GelMA/CAT nano@microgel, in both in vitro and in vivo ovarian cancer models (Schematic Figure). The gene discussed is CAT; the disease is ovarian carcinoma.