CDH5 and cancer: Anti-PFKFB3-mediated glycolysis reduction resulted in a stiffened vascular fence by decreasing vascular endothelial cadherin (VE-cadherin) endocytosis in TECs, rendering pericytes more dormant and adhesive (highly positive for N-cadherin expression) and downregulating NF-κB signaling, which reduced cancer cell adhesion molecules in TECs [89].