The immunohistochemical analysis of the skin biopsy samples from five patients who experienced postural tachycardia syndrome after SARS-CoV-2 infection showed the presence of the α-synuclein in a phosphorylated form, the pathological state of α-synuclein in PD or dementia with Lewy bodies, multiple system atrophy and pure autonomic failure (135). Here, SNCA is linked to multiple system atrophy.