Figure 2 shows that rs690, rs6083, rs3829461, and rs6074 in LIPC had antagonistic effects on stroke risk. In the MDR analysis, by comparing the parameters of cross-validation consistency (CVC), OR, 95% CI, p-value, training balanced accuracy (Bal. Acc). , and testing balanced accuracy, we found that the four-locus model consisting of four SNPs (rs690, rs6083, rs3829461, and rs6074) was the best one to assess the risk of stroke (CVC: 10/10; Testing Bal. Acc = 0.519; OR = 1.66, 95% CI: 1.32–2.07, p = 0.0001, Table 6). Here, LIPC is linked to Stroke.