Several intronic- and exonic-missense and silent mutations were detected in sporadic HBL tumors using NGS in genes such as ALK, KDR, CTNNB1, PIK3CA, FGFR3, FGFR2, HRAS, HNF1A, SMO, and TP53 [13]. The gene discussed is PIK3CA; the disease is hepatoblastoma.