The insertion frameshift variant in NRAS and deletion variant in HNF1A genes was also novel. The four synonymous variants detected in the HBL tumor of the present study, in genes such as MLH1, ALK, KDR, and ABL1, were not reported previously. Among the three intronic variants detected in the SND1 gene in the HBL tumor, two of which were novel. Only one 3’-UTR variant in the CSDE1 gene and an intronic splice_donor_variant of the TP53 gene was found in the HBL tumor. This evidence concerns the gene KDR and hepatoblastoma.