The sleep impairment occurring the greatest frequency in AD mouse lines appears to be the reduction of NREM sleep duration and concurrent increase in wakefulness, which has been reported in homozygous AppNL-G-F, TgCRND8, AβPPswe/PS1∆E9, PLB1, and APP23 mice among others (Supplementary Table 2; Jyoti et al., 2010; Platt et al., 2011; Roh et al., 2012; Colby-Milley et al., 2015; Holth et al., 2017a; Van Erum et al., 2019; Zhang et al., 2019; Holton et al., 2020; Maezono et al., 2020; Beuckmann et al., 2021). Here, PLB1 is linked to Alzheimer disease.