Certain AD models, such as the homozygous AppNL-G-F, PDAPP, and P301S tau models are reported to express decreased REM sleep durations prior to exhibiting altered wakefulness or NREM sleep durations (Huitrón-Reséndiz et al., 2002; Holth et al., 2017a; Maezono et al., 2020). The gene discussed is MAPT; the disease is Alzheimer disease.