While soluble and insoluble Aβ are often suspected of being primary contributing factors towards progressive sleep deterioration in AD, it is important to consider mouse lines that exhibit sleep impairment despite the lack of Aβ pathology, such as the P301S Tau (PS19) and rTg4510 mouse models (Holth et al., 2017a; Holton et al., 2020). The gene discussed is MAPT; the disease is Alzheimer disease.