In their study, Holton et al. (2020) demonstrated that repression of tauopathy with doxycycline prevented or lessened most longitudinal EEG changes in rTg4510 mice, indicating that tauopathy may be the chief cause of the altered EEG and sleep behavior in a tau-based model of AD (Holton et al., 2020). The gene discussed is MAPT; the disease is Alzheimer disease.