PSEN1 and Alzheimer disease: The 3xTgAD mouse is a triple transgenic model that incorporates the hAPP transgene with the Swedish mutation, human PS1 transgene with an M146V mutation, and human tau transgene with the P301L mutation, making it one of a limited number of AD models that express both, Aβ plaques and tau NFTs (Sterniczuk et al., 2010).