Next, we sought to explore the levels of APP and Aβ which are regarded as a hallmark of AD and AD-like models, and are shown to be significantly increase following STZ application (Salkovic-Petrisic et al., 2013; Alluri et al., 2020; Gáspár et al., 2021; Singh and Garabadu, 2021). The gene discussed is APP; the disease is Alzheimer disease.