Increased production of APP initiates various cellular signaling cascades, one of them being the transcription of the EGR1 gene (Hendrickx et al., 2013), which is markedly increased in the STZ-induced model of AD-like pathology (Alluri et al., 2020) and may regulate levels of Aβ (Qin et al., 2017). Here, EGR1 is linked to Alzheimer disease.