For example, we found that visual or auditory GENUS reduced phosphorylated tau in the respective sensory cortices of Tau P301S tauopathy model mice (Allen et al., 2002) when used for 1 h/day for 7 days (Iaccarino et al., 2016; Martorell et al., 2019), and that visual GENUS ameliorated neuronal loss when used for 3 weeks (Adaikkan et al., 2019). This evidence concerns the gene MAPT and tauopathy.