MAPT and tauopathy: Increased tau aggregation is considered a hallmark pathology of several different neurodegenerative conditions—known as tauopathies—and can be triggered by mutations in the tau gene (MAPT; Wang and Mandelkow, 2016) or hyperphosphorylation of certain residues in the tau protein (Miao et al., 2019; Xia et al., 2020, 2021).