ALDH7A1 and Alzheimer disease: AD patients exhibited decreased esterified ends with age, whereas control subjects exhibited higher esterified ends with age. Control subjects exhibited lower PDE with age. Mildly AD patients exhibited higher PME and lower PCr and ionized ends as compared to controls. Moderate AD patients did not differ from controls in any HEP or phospholipid metabolite. PME was positively correlated and PCr and ionized ends were negatively correlated with the Mattis score in AD patients. Pi was negatively correlated with the Mattis score in controls. No group differences in pH.