ALDH7A1 and Alzheimer disease: Memantine, an N-methyl-D-aspartate (NMDA) receptor antagonist used to treat symptoms of AD, was reported to increase ATP and lower Pi/ATP in young adult men during a period of hypoglycemia, though there was no effect on PCr, Pi, PCr/Pi, or PME and PDE (Willenborg et al., 2011).