CTHRC1 overexpression has been observed in various solid human malignant tumors, including melanoma, gastric cancer, colorectal cancer, breast cancer, and thyroid cancer (Ip et al., 2011; Jiang et al., 2020; Kim et al., 2013; Tang et al., 2006; Wang et al., 2012). Here, CTHRC1 is linked to thyroid cancer.