ERBB2 and breast carcinoma: Breast cancer subtypes were also classified [53] according to immunohistochemical profile as follows: luminal A [Hormone receptors (HR)-positive, HER-2 negative, Ki-67<14%], luminal B (HR-positive, HER-2 negative, Ki-67≥14%), luminal B/HER-2 (HR-positive and HER-2 positive), HER-2 enriched (HR-negative and HER-2 positive), and TNBC (HR- and HER-negative).