IL6 and systemic lupus erythematosus: In order to examine whether IL-6 could conduct ferroptosis resistance in lupus kidney B cells via SLC7A11 in vivo, we treated lupus animals with sulfasalazine and found the Fe2+-enriched B cell numbers were drastically increased after blocking SLC7A11 (Figures 4(a)–4(c)), indicating SLC7A11 could be the key factor that drives B cells to develop ferroptosis, induced by IL-6, the cytokine mainly expressed by neutrophil (Ly6g).