As expected, blocking IL-6 significantly increased the Fe2+ signals (Figures 3(b) and 3(c)) and lipid peroxidation (Figures 3(d) and 3(e)) in B cells isolated from lupus animal, together with altered GSH and GSSG/GSH ratio (Figures 3(f) and 3(g)), key indicator for ferroptosis [20, 21] but had no obvious effect on B cells isolated from healthy controls, suggesting IL-6 could suppress ferroptosis/ferroptosis resistance in lupus B cells. The gene discussed is IL6; the disease is systemic lupus erythematosus.