In WDOSCC, among 14 positive cases, six cases showed PDPN expression in the tumor cells at the periphery of the islands, and eight cases showed positivity in both central and peripheral cells of the tumor islands. In MDOSCC, 4 out of 15 cases showed positive expression limited to the periphery, whereas the remaining 11 cases showed PDPN expression in the entire tumor islands. Here, PDPN is linked to neoplasm.