PDPN and lip and oral cavity carcinoma: The enhanced immunoexpression of PDPN signifies that this immunomarker can have a role in the tumor cell differentiation and neoplastic progression of OSCCs. In OPMDs like OL, showing increased PDPN expression has been found to be related to a high risk of progression to invasive oral cancer, thereby suggesting that it might act as a powerful tumor marker to predict the risk of malignant transformation in OL patients.