*Statistically significant. NS: non-significant, PAD: peripheral artery disease, HIV: human immunodeficiency virus, AF: atrial fibrillation, AFL: atrial flutter, COPD: chronic obstructive pulmonary disease, PE: pulmonary embolism, DVT: deep venous thrombosis, OSA: obstructive sleep apnea, CKD: chronic kidney disease, ESRD: end-stage renal disease, CAD: coronary artery disease, ACE-I: angiotensin-converting enzyme inhibitor, ARB: angiotensin receptor blocker, OAC: oral anticoagulant use. This evidence concerns the gene ACE and chronic obstructive pulmonary disease.