TLR5 and Global developmental delay: The gene DISP1 is involved in sonic hedgehog signaling, and microdeletions of this gene have been associated with developmental delay and dysmorphic features.36 In experimental models, sonic hedgehog signaling can accelerate fibrosis postkidney injury and contribute to the development of CKD after AKI.37,38 The gene TLR5 plays a fundamental role in pathogen recognition and activation of innate immune responses, and TLR5 is highly expressed in the kidneys.