Investigators demonstrated that a TLR5 agonist attenuated kidney injury in a murine model of radiation-induced renal failure and ischemia/reperfusion-induced renal failure through decreased accumulation of reactive oxygen species.39,40 This background knowledge supports that the variants, rs17538288 and rs7546189, may influence the risk of AKI through DISP1 and/or TLR5 signaling. The gene discussed is DISP1; the disease is acute kidney injury.