Examination of single-cell RNA sequencing analyses from kidney biopsies completed in hospitalized patients with AKI through the KPMP19 initiative demonstrated that DISP1 and TLR5 were expressed in multiple kidney cell types, including proximal tubular epithelial cells and thick ascending limb of the loop of Henle (TAL) (Figure 3). This evidence concerns the gene TLR5 and acute kidney injury.