However, PTEN deficiency has recently also been associated with an APDS-like clinical phenotype, including autoimmunity, lymphoid hyperplasia, hypogammaglobulinemia, reduced responses to vaccinations and recurrent infections, CD4+ T cell lymphopenia, transitional B cell accumulation, and reduced memory B cells (Browning et al., 2015; Chen et al., 2017; Driessen et al., 2016; Tsujita et al., 2016). Here, CD4 is linked to Autoimmunity.