Typical clinical features of NFKB2 deficiency are early onset hypogammaglobulinemia, recurrent respiratory infections, poor Ab responses to vaccines, autoimmunity, and adrenocorticotropic deficiency (Brue et al., 2014; Chen et al., 2013; Klemann et al., 2019; Lee et al., 2014; Liu et al., 2014). Here, NFKB2 is linked to agammaglobulinemia.