CRC cells are more efficient than non-malignant cells in metabolizing lipid-derived electrophiles into non-toxic conjugates due to the higher expression of key biotransformation enzymes, attributable to constitutive Kelch-like ECH-associated protein 1 (KEAP1)/Nuclear factor erythroid 2-related factor 2 (NRF2) activation [140]. This evidence concerns the gene NFE2L2 and colorectal carcinoma.