The immunological features of the patient are reported in Table S3 and include eosinophilia (maximum value 6.36 × 109/L), high IgE levels (up to 3258 IU/L), low levels of T and B memory cells, Th17 cell levels within the normal range, and unusually low levels of inflammation markers during severe infection (e.g., C-reactive protein at 39 mg/L during miliary tuberculosis and 33 mg/L during necrotizing pneumonia) (Fig. 1G). Here, IGHE is linked to miliary tuberculosis.