LOXL2 and pulmonary fibrosis: Additionally, the progressive increase in 64Cu-LLP2A uptake from week-1 to week-4 post-bleomycin correlated with the extent of lung fibrosis and ECM remodeling at week-4 post-bleomycin among the survivors of the longitudinal studies as estimated by the hydroxyproline content of the lungs and the mRNA expression of markers of ECM remodeling, including Col1a1, Fn1, Lox, and Loxl2 (Fig. 3C).