Other types of tumorigenesis, including gastrointestinal stromal tumors (GISTs), renal, thyroid, melanoma, sarcoma, colon neuroblastoma [30, 33], pancreatic neuroendocrine tumors, Carney triad, and ganglioneuroma [34] have been shown to depend on SDH family mutations in some cases. The gene discussed is SDHB; the disease is pancreatic neuroendocrine tumor.