So KPC-ABHD17C-vector-LDHA-Ctrl, KPC-ABHD17C-vector-LDHA-KD, KPC-ABHD17C-OE-LDHA-Ctrl, KPC-ABHD17C-OE-LDHA-KD were constructed for subsequent research (Fig. 6a), and the growth of KPC-ABHD17C-OE-LDHA-KD tumor was significantly slower than that of KPC-ABHD17C-OE-LDHA-Ctrl with complete glycolysis (Fig. 6b, Supplementary Fig. 4a, b). Here, LDHA is linked to neoplasm.