As our schematic diagram of this research shows (Fig. 8a), on the one hand, the elevation of tumor-derived ABHD17C in PDAC could significantly increase the expression of MCT1, MCT4, GLUT1, GLUT4, and LDHA at protein and mRNA levels, which increased glycolytic levels of tumor cells and the production of acidic metabolites in the microenvironment. Here, SLC2A1 is linked to neoplasm.