Among the complex DNA methylated targets, an elevated expression of transcription (STAT) 3, known as a master transcription factor mediating a wide range of cell functions of MDSCs [24], has been widely defined as the result of hypomethylated promoter silencing due to the attenuated DNMT3A/3B in various cancers including lung, pancreas and renal cancer [152–155]. Here, DNMT3A is linked to cancer.