EZH2 and lung carcinoma: As an example, it’s been reported that the downregulation of lysine methyltransferase EZH2 resulted in the reduction of histone H3 lysine 27 (H3K27me3) in lung cancer [61], while the activation of histone H3 lysine 4 (H3K4) and the subsequent elevation of the antioxidant signaling pathway in prostate cancer was discovered owing to the lysine methyltransferase 7 (SetD7) [62].