FOXP3 and neoplasm: Except for regulations in CXCL9/CXCL10, histone modification also controls immunological functions of TILs through various mechanisms, for example, Forkhead box P3 (Foxp3), a master lineage-specific phenotypic protein of Treg cells, was proven to play a new role in the TME by combined with HAT1 to control CC chemokine receptor 4 (CCR4) expression via providing provocative (K23 and K27) or repressive (K14 and K18) acetylation to H3, thus influencing the infiltration of Treg cells and anti-tumor immunity [221].