For instance, TNF- and CD45-targeting miRNAs such as miR-498, miR-181a/b, and miR-3187-3p could be released from melanoma cells to suppress the immunological function of CD8+ T cells [223], while delivering miR-142-5p from cervical squamous cell carcinoma (CSCC) cells to lymphatic endothelial cells (LECs) was considered as an integral component of the immune checkpoint, which could suppress and exhaust CD8+ T cells through AT-rich interactive domain-containing protein 2 (ARID2)-DNMT1-IFN-γ signaling and the elevated expression of indoleamine 2,3-dioxygenase (IDO) in the downstream [224]. The gene discussed is ARID2; the disease is melanoma.