Following m6A sequencing revealed that YTHDF1-mediated translation of Sprouty-related, EVH1 domain containing 2 (SPRED2), which is responsible for inducing NF-κB and STAT3 through the ERK pathway, was impaired by the loss of METTL3 [173, 174], highlighting the m6A machinery as a potential cancer immunotherapy target. The gene discussed is NFKB1; the disease is cancer.