TGFB1 and breast cancer: Intriguingly, Tang et al. discovered a positive feedback loop that facilitated TGF-β autocrine in breast cancer, where TGF-β1 could activate DNMT3B and thus suppressed the expression of miR-200a, miR-200b, miR-200c and miR-141, leading to enhanced sensitivity of CAFs to TGF-β1 [137].