As an illustration, circRNA NOP2/Sun RNA methyltransferase 2(circNSUN2), prominently elevated in the cytoplasm of colorectal carcinoma (CRC) cells under m6A modification, stabilizes the structure of high mobility group AT-hook 2 (HMGA2) mRNA via interacting with an RNA-binding protein called Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 (IGF2BP2), ultimately enhancing the aggressive of CRC cells [352]. The gene discussed is IGF2BP2; the disease is colorectal carcinoma.