MEOX1 and intrahepatic cholangiocarcinoma: Except for CLOCK, generally relevant to circadian rhythms but exhibited as the histone acetyltransferase in glioblastoma as mentioned before [127], Alvisi., et al. [344] lately manifested that in intrahepatic cholangiocarcinoma, the high enrichment of a novel transcription factor in tumor-infiltrating Tregs, mesenchyme homeobox 1 (MEOX1), was closely related to EZH2, further reprogram circulating Tregs.