Despite the global DNA methylation, gene expression of Th1 chemokines CXCL9 and CXCL10 was mediated by EZH2 and DNMT1, dampening CD8+ T cell infiltration in ovarian cancers [126], and the demethylation state of promoters in Th1 was proven as a significant mediator to IFN-γ production in colon cancer lymphocytes [214]. This evidence concerns the gene CXCL9 and malignant colon neoplasm.