Intriguingly, a very recent study reported that silencing voltage-dependent anion-selective channel protein 1 (VDAC1) in neoplastic cells could not only inhibit tumor-mediated angiogenesis, but has an overall impact on a battery of TME-associated genes involved in extracellular matrix construction, and intercellular interaction in LC, highlighting the therapeutic potential of siVDAC1 in stromal-abundant solid tumors [262]. This evidence concerns the gene VDAC1 and neoplasm.