Chan et al. found that decitabine and 5-AZA could rescue NK cells from a metastasis-favoring phenotype in breast cancer by hypomethylation-induced repression of NK-inhibiting genes including T cell immunoreceptor with Ig and ITIM domains (TIGIT) and killer cell lectin like receptor G1 (KLRG1) [267]. The gene discussed is KLRG1; the disease is breast cancer.