As an example, USP24, a deubiquitinating enzyme upregulated in M2 macrophages of lung cancer cells, could stabilize HAT p300 thus increase H3 acetylation and NF-κB while decrease DNMT1, subsequently elevating TNF-α and IL-6 transcription, ultimately resulting in cancer malignancy [175]. This evidence concerns the gene DNMT1 and lung carcinoma.