AK001796 has been found to regulate cellproliferation, cell cycle via modulating MDM2/p53 signaling in ESCC and increase theresistance of NSCLC cells to cisplatin by impacting cell apoptosis and cellproliferation (Liu et al., 2017; Liu et al., 2018). This evidence concerns the gene MDM2 and esophageal squamous cell carcinoma.