KMT2A and acute myeloid leukemia: The proliferation of AML cells was inhibited by up to 90% after the cells were treated with low micromolar or sub-micromolar concentration of fadraciclib for 6 h.105 Sensitivity to fadraciclib was found to increase in AML and ALL cell lines carrying MLLr/MLL-PTD, which may be due to their dependence on the MLL-mediated transcription of HOXA9/MEIS1.