VEGFA and neoplasm: CAN508 has been shown to exhibit anti-proliferative activity toward tumor cell lines (MCF7, OE33, FLO-1, and SKGT4).86 In addition, CAN508 was demonstrated to have antiangiogenic activity in cell migration and tube formation toward primary endothelial cells (HMEC-1 and HUVEC) by reducing VEGF and ICAM production.87 In xenograft models (FLO-1), CAN508 caused reduction of tumor growth without significant signs of toxicity as monitored by body weights.88