It does not affect the cell cycle, but mediates caspase3-induced apoptosis.108 However, because of the high expression of CDK9 in the gastrointestinal epithelium even at the lowest dose (2.5 mg/kg every 3 days), THAL-SNS-032 induced severe gastrointestinal disorders in mouse models due to an on-target off-tumor effect of the compound. The gene discussed is CDK9; the disease is neoplasm.