1) Mixed lineage leukemia (MLL) gene on chromosome 11q23 encodes a histone 3 lysine 4 methyltransferase protein (MLL).69MLL always undergoes a trans-location mutation fusing with 3’ end of various genes (mainly nuclear transcription factors including AF4, AF6, AF9, AF10, AF17, AF1p, ENL, ELL, and SEPT6) by its 5’ end, accounting for 10% of all acute leukemias.69,70 Most of these partner genes are responsible for recruiting P-TEFb and enhancing the expression of HOX, MEIS1, and FLT3, which drive leukemogenesis. Here, KMT2A is linked to acute leukemia.