Transient exposure to AZD4573-induced apoptosis in MV4–11 cells (as well as MOLP-8, OCI-LY10, and NCI-H2122 cell lines, although some cancers rely on survival factors other than MCL-1) mainly by reducing the phosphorylation of pSer2-RNAP II, which led to a decrease in MCL-1.46,102 Therefore, AZD4573 has a potential antitumor effect on MCL-1-dependent hematological malignant tumors. This evidence concerns the gene MCL1 and cancer.