RPS19 and Diamond-Blackfan anemia: Altogether, these results show that Rps12 is required for erythroid differentiation, and demonstrate a role for Rps12 in erythropoiesis, similar to what has been observed in mouse models of DBA genes like Rpl11, Rps19, and Rps14 (Jaako et al., 2011; Morgado-Palacin et al., 2015; Schneider et al., 2016).