Mutations in Rp genes of both the large and the small ribosomal subunits have been found to have similar phenotypes to those of DBA patients, such as impaired erythropoiesis, skeletal defects, and increased incidence of cancer, including some Rp not yet implicated in DBA (Oliver et al., 2004; McGowan et al., 2008; Jaako et al., 2011; Terzian et al., 2011; Morgado-Palacin et al., 2015; Schneider et al., 2016). The gene discussed is BLOC1S3; the disease is Diamond-Blackfan anemia.