RHO and retinal degeneration: The ERG results were consistent with the hematoxylin and eosin (HE) and IF results, which showed that Mut-Rhowt/hum mice lost photoreceptors slowly, and the OS/IS length of photoreceptor cells became shorter, with increasing age (Figure 5—figure supplement 2B–D), indicating the pattern of retinal degeneration caused by mutant human rhodopsin was a typical rod-cone decay.