RHO and retinal degeneration: Furthermore, a human RHO-knock-in (RHO humanized) mouse model (Liu et al., 2022) generated previously can simulate pathological changes in RHO-adRP, the retinal degeneration might be caused by any one of the five variants (T17M, G51D, G114R, R135W, and P171R, RHO-5m).