For example, elevation in serum LH and FSH levels in the context of low sex-steroids (hypergonadotrophic hypogonadism) typically indicates primary hypogonadism e.g. POI as a cause of secondary oligo/amenorrhoea and primary gonadal insufficiency in delayed puberty [18]. The gene discussed is PLOD1; the disease is Hypergonadotropic hypogonadism.