BRD2 and primary ovarian failure: In a study of 1,998 women aged under 40 years with different ovarian reserve, subdivided into control with normal ovarian reserve (NOR, n=987), pre-POI (n=410; FSH>10 IU/L but ≤25 IU/L), early POI (n=147; FSH >25 IU/L but ≤40 IU/L), and ‘premature ovarian failure’ (n=454; defined as FSH >40 IU/L) group, an AMH of ≤0.25 ng/ml was diagnostic of POI with a sensitivity of 92.46% and specificity of 90% [89].