PLOD1 and polycystic ovary syndrome: Intravenous infusion of rLH following pre-treatment with GnRH antagonist (to block endogenous LH secretion) and dexamethasone (to block adrenal androgen secretion) in women with PCOS results in significant increase in the mean plasma 17-OHP (0.78 vs 0.33 ng/ml) and testosterone (0.86 vs 0.32 ng/ml) compared with controls [73].