In one report from Vietnam, an LH:FSH ratio cut-off of 1.33 provided an area under receiver operating characteristic curve (AUROC) of 0.87 (95% CI: 0.84–0.89) to distinguish PCOS from healthy controls, and a one unit increase in LH:FSH ratio was associated with 14-fold increased odds of PCOS [44]. Here, PLOD1 is linked to polycystic ovary syndrome.