In women with PCOS (n=8), LH responses, and ovarian steroid intermediates – 17-hydroxyprogesterone (17-OHP) and androstenedione levels were significantly higher than in controls (n=16) in response to nafarelin [71], postulated to be secondary to abnormal regulation of 17-hydroxylase and 17,20-lyase activities within the theca cells. Here, PLOD1 is linked to polycystic ovary syndrome.