Using a maximal LH response threshold at 3hrs post-triptorelin of >7 IU/L by immunofluorometric assay (IFMA), or >8 IU/L by electrochemiluminescence immunoassay (ECLIA), confirmed the diagnosis of CPP with a specificity of 100% (95% CI: 75–100%) and sensitivity 76% (95% CI: 58–89%) [65]. Here, PLOD1 is linked to central precocious puberty.