In women with PCOS, administration of hCG results in reduction of INB levels (pre-hCG 223.8 vs post-hCG 152.4 pg/ml), whilst diazoxide (which blocks insulin secretion) results in significant increase in INB levels (pre-diazoxide 85.4 vs post-diazoxide 136.6 pg/ml) [79]. The gene discussed is CGA; the disease is polycystic ovary syndrome.