Specifically, given previous reports that GDF15 impacts cell viability via β‐catenin47, 48 and considering that JAG1 is a direct target gene of β‐catenin in colorectal cancer cells,49 we conducted qPCR and immunoblotting analyses of siRNA‐mediated knockdown of GDF15 in HTR‐8/SVneo cells and found that GDF15 upregulated β‐catenin and JAG1. Here, GDF15 is linked to colorectal cancer.