Among the top 15 genes upregulated in db/db mice, Cyp4a14 plays an important role in the development and progression of NAFLD (Zhang et al, 2017), Pebp1 is an inflammatory and immune system modulator (Lai et al, 2017; Gabriela‐Freitas et al, 2019), and Tat plays an important suppressive role in the development and progression of HCC (Fu et al, 2010). Here, TAT is linked to hepatocellular carcinoma.