In addition, overexpression of DIO3OS led to a significantly reduced xenograft incidence of SK‐Hep1 cells in the subcutaneous transplantation of serially decreasing numbers of tumor cells in nude mice, suggesting an in vivo repressing role of DIO3OS in HCC stemness (Figure 2K; Figure S2C–E, Supporting Information). This evidence concerns the gene DIO3OS and neoplasm.