Indeed, DIO3OS was recently reported to play a regulatory role in multiple cancers, including HCC, in a trans manner.[22, 35, 36, 37] Our results on the DIO3OS‐modulating cancer phenotype, including proliferation and motility, were largely in accordance with those of previous studies, suggesting a robust tumor‐suppressing role of DIO3OS in HCC. Here, DIO3OS is linked to hepatocellular carcinoma.