TNF and neoplasm: However, treatment of ITF2357, I‐BET151, or JQ1 only on T cells directly isolated from the OT‐I mouse spleen did not increase the secretion levels of IFNγ, GZMB, or TNFα (Figure S4A,B, Supporting Information), suggesting the drug effects are dependent on the interaction of T cells with the tumor or other stroma cells in the organoids.