Particularly, pancreatic tumors have dense fibrotic stroma that acts as a physical barrier for immune cell infiltration and TAMs that express negative regulators (such as PD‐L1) against the functionality of T cells.[44, 45] Modeling the immunosuppressive TME is the key for a 3D organoid platform in drug screen for PDA immunotherapy.[46] In this study, the T‐cell‐incorporated organoid model comprises tumor epithelial cells, endothelial cells, tumor‐associated fibroblasts (PSCs and activated fibroblasts), and TAMs. This evidence concerns the gene CD274 and neoplasm.