M1 macrophages are known to have an anti‐tumor activity by producing pro‐inflammatory cytokines, promoting T cell activation, and inducing tumor cell apoptosis.[40] The increased number and activation of M1 macrophages (CD11b+F4/80+Gr1−I‐A/I‐E+) in response to the drug treatment alone or in combination with ICB could enhance the cytotoxicity of T cells against tumor cells, leading to a more effective anti‐tumor response (Figure 6A, Figures S6D and S7, Supporting Information). The gene discussed is ITGAM; the disease is neoplasm.