MKI67 and bone metastasis: In univariate Cox regression analysis, the presence of bone metastasis (OR = 1.982, 95%CI 1.164–3.373, P = 0.012), good necrosis (≥ 90%, OR = 0.158, 95%CI 0.056–0.448, P = 0.001), elevated Ki-67 (OR = 3.074, 95%CI 1.183–7.987, P = 0.021), elevated LDH (OR = 2.082, 95%CI 1.249–3.470, P = 0.005) and elevated ALP more than two times (OR = 2.262, 95%CI 1.246–4.106, P = 0.007) were associated with the occurrence of MLM.