In contrast, ASPA knockdown resulted in increased tumor weights and up-regulated expression of PCNA, cyclin D1, N-cadherin, and MMP9 (P < 0.05 or P < 0.01), concomitant with the inhibition of E-cadherin expression (P < 0.01; Fig. 4p–r). This evidence concerns the gene ASPA and neoplasm.