CNTNAP2 and epilepsy: They found that CNTNAP2 underwent activity-dependent ectodomain shedding and released a soluble extracellular fragment (CNTNAP2 ectodomain), which is involved in the regulation of Ca2+ homeostasis and network synchrony.52 While our data indicate that CICD is largely, if not all, responsible for the autism-related behaviors, the CNTNAP2 ectodomain may underlie the epilepsy in Cntnap2−/− mice.