JUN and cancer: Indeed, curcumin is known to act on multiple signaling pathways and recognizes a plethora of molecular targets involved in cancer development [128] including cyclooxygenase (COX)-2, cytokines, transcription factors like protein kinase B, NF-κB, signal transducer and transcription activator 3 (STAT3), activator protein 1, and telomerase [129,130].