Pan-reactive astrocyte genes (Cxcl10 and Osmr), A1 neurotoxic genes (Amigo2, Ugt1a, Gpc4, H2-D1, and Iigp1), and A2 neuroprotective genes (Ptx3, Thbs2, and Tm4sf1) were all upregulated by NPD1 + RvD1 in the ipsilesional penumbra at 24 h after stroke. This evidence concerns the gene GPC4 and stroke disorder.