Higher methylation of ITGA3, ITGA6, ITGB3, ITGB4, ITGB8, ITGBL1, and ITGB5 were associated with higher infiltration of CD8+ T cells into tumor sites, while ITGA9, ITGAM, ITGA7, ITGAE, ITGB2, ITGA4, ITGA8, and ITGAL had a negative impact in pancreatic cancer. Here, ITGA9 is linked to familial pancreatic carcinoma.