TNF and neoplasm: Exhausted CD8 T cells exhibit impaired cytokine production29–31 so, we also measured interferon γ (IFNγ) and tumor necrosis factor α (TNFα) production using our in vivo tumor model and observed that there were modest, albeit non-significant increases in dual IFNγ and TNFα production by transferred CD45.1+Lpar5−/− OT-I CD8 T cells as compared to wildtype CD45.1+ OT-I CD8 T cells (Supplementary Fig. 6).