Using our systemic in vivo tumor model, we investigated additional markers of CD8 T cell exhaustion and these analyses showed that transferred CD45.1+Lpar5−/− OT-I CD8 T cells isolated from tumors in the lungs expressed reduced amounts of Lag3 and Tox as compared to wildtype transferred CD45.1+ OT-I CD8 T cells (Fig. 3K–P). Here, TOX is linked to neoplasm.