Remarkably, an analysis of common gene expression changes due to loss or inhibition of Cxcr2 during tumorigenesis converged on one, but only one, gene – the tumor suppressive transcription factor Tfcp2l1. These data indicate that one mechanism by which Cxcr2 inhibition regulates melanoma tumor growth is via induction of a key transcription factor, Tfcp2l1. Tfcp2l1 is a member of the Tfcp2/Tfcp2l1/Ubp1 subfamily of Grainyhead-like transcription factors. Here, CXCR2 is linked to melanoma.