Following a month of continuous feeding on control or SX-682-containing chow, we observed that Braf/Pten mice fed SX-682-containing chow exhibited a trend toward reduction in tumor volume compared to mice fed vehicle control chow (Fig. 4A, p = 0.07; 802.5 ± 724.01mm3 for control; 230.20 ± 373.21 mm3 for SX-682). The gene discussed is PTEN; the disease is neoplasm.