To elucidate the mechanism by which Cxcr2 perturbation in melanocytes could alter the initiation and growth of BrafV600E/Pten−/− (Braf/Pten) melanoma, we examined the transcriptome of tumors arising in Braf/Pten/Cxcr2WT (n = 7) and Braf/Pten/Cxcr2−/− (n = 8) mice via RNA sequencing (RNAseq) analysis (Figs. 2C, S3A, S4). This evidence concerns the gene CXCR2 and melanoma.