PGR and endometriosis: The eutopic and ectopic endometria from patients with endometriosis showed decreased expression levels of CFP1, GATA2, SOX17, and IHH mRNAs compared with the endometrium from the control group (Fig. 5c, d), suggesting that reduced CFP1 expression may disturb epigenetic landscapes that mediate P4-PGR signaling pathways in human endometrium, often leading to endometriosis.