To test this, we examined the ability of iASPP to regulate the pancreatic inflammatory response and PC formation in oncogenic KRAS-driven pancreatitis and PC models using pancreas-specific (Pdx1-Cre) compound transgenic mice expressing mutant KRAS in the presence or absence of iASPP (exon-8 deletion). The gene discussed is PPP1R13L; the disease is pancreatitis.