We investigated the effect of iASPP on tumour development in the presence of WT p53 using Pdx1-Cre to express oncogenic KRASG12D (KC) alone or concurrently delete iASPP to generate KC and KC;iASPPΔ8/Δ8 mice respectively (Supplementary Fig. S1A). The gene discussed is PDX1; the disease is neoplasm.