Considering EGFR is a common upstream activator for the JAK2-STAT3 and PI3K-AKT signaling pathways and plays an important role in the progression of NSCLC [30, 31], we inputted the DEGs screened from shKrm2 H1703 cells into FunRich software (version 3) for functional analysis. This evidence concerns the gene JAK2 and non-small cell lung carcinoma.