Recently, we also described that hematopoietic stem cells (HSCs), from Rosa26-LoxP-STOP-LoxP-hSETBP1G870S crossed with Vav::Cre mice, transplanted in sub-lethally irradiated mice lead to lethal anemia (Crespiatico, Zaghi et al., submitted). The gene discussed is VAV1; the disease is anemia.